靶点科技(北京)有限公司 代理商

6 年

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靶点科技(北京)有限公司

入驻年限:6 年

  • 联系人:

    技术支持

  • 所在地区:

    北京 丰台区

  • 业务范围:

    细胞库 / 细胞培养、试剂、技术服务

  • 经营模式:

    生产厂商 代理商

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技术资料/正文

Science: Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis

242 人阅读发布时间:2019-11-12 22:16

Sepsis is a frequently fatal condition characterized by an uncontrolled and harmful host reaction to microbial infection. Despite the prevalence and severity of sepsis, we lack a fundamental grasp of its pathophysiology. Here we report that the cytokine interleukin-3 (IL-3) potentiates inflammation in sepsis. Using a mouse model of abdominal sepsis, we showed that innate response activator B cells produce IL-3, which induces myelopoiesis of Ly-6Chigh monocytes and neutrophils and fuels a cytokine storm. IL-3 deficiency protects mice against sepsis. In humans with sepsis, high plasma IL-3 levels are associated with high mortality even after adjusting for prognostic indicators. This study deepens our understanding of immune activation, identifies IL-3 as an orchestrator of emergency myelopoiesis, and reveals a new therapeutic target for treating sepsis.

资料格式:

Science文献1.pdf

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